A
farewell symposium will be organised in honour of Prof.Dr. Jan Reedijk
on the occasion of his retirement from the Chair of Inorganic Chemistry
at Leiden University that he has occupied since November 1, 1979.
The morning session of the symposium comprises contributions from
former group members and ends with a reunion lunch for the attendees.
The formal symposium in the afternoon comprises two contributions
of internationally renowned speakers. Jan Reedijk will then conclude
the symposium with his farewell lecture.
After the symposium, all attendees will have the opportunity to
drink a toast to Jan Reedijk during the reception in the central
hall of the Gorlaeus laboratories.
Gorlaeus laboratories, Einsteinweg 55, 2333 CC Leiden
Pretargeted radioimmunotherapy and -imaging enables significant increases in tumor/non-tumor ratios of radioactivity. After injection and tumor localization of a large and slow antibody, a small and fast probe consisting of a radiometal complex conjugated to an antibody-binding moiety is injected and quickly binds the antibody. To address the drawbacks of the currently used biological antibody-probe binding systems we designed a novel pretargeting methodology based on bio-orthogonal chemical ligation reactions. This methodology allows selective conjugation of a chemically modified antibody with a radiometal complex functionalized with the complementary chemical group.
Various poly-beta-Diketophenols have been prepared and used as rigid ligands for the assembly of a rich category of metallosupramolecular assemblies. The structure of these organic donors determines the metal topologies of the final coordination complexes, which include arrays with fundamental interest, such as metallic nanowires or pairs of weakly interacting clusters.
Natural products containing phosphorus-carbon bonds have found widespread use in medicine and agriculture. One such compound is phosphinothricin (PT). Recent genetic and biochemical studies showed that during PT biosynthesis 2-hydroxyethylphosphonate (HEP) is converted to hydroxymethylphosphonate (HMP) by a non-heme iron-dependent enzyme. Mechanistic studies into this unprecedented C-C bond cleavage reaction will be presented.
12.15-13.45
buffet lunch for (former)
group members CBAC (Gorlaeus canteen)
Previous work has shown that {Cr7Ni}
heterometallic rings have many of the properties required
for individual qubits - isolated S = 1/2 ground
states and sufficiently long coherence times. Here we
report studies where the rings are linked into supramolecular
arrays including rotaxanes, dimers, trimers, tetramers
and polymers.
The role of metal complexes as therapeutic and diagnostic agents is burgeoning due to interest from many academic and industrial concerns; the current value of medicinal inorganic chemistry is in excess of 109 $. Cis-platin, for example, is the archetypal inorganic drug containing as it does, no atoms of carbon. Principles in the design of metal compounds as drugs will be discussed in detail with examples from work in the speaker's research laboratories presented to illustrate these principles. A number of vanadium compounds have insulin-enhancing properties, most notably when administered orally (a route via which insulin is not active). Gastrointestinal absorption of vanadium is usually poor and depends on the chemical nature, solubility, and speciation of the specific metal ion complex. We have discovered an orally effective therapeutic agent that is a potent insulin-enhancing drug and is now in phase 2 clinical trials. Also presented will be new carbohydrate conjugates for diagnosis and therapy.
15.30-16.00
coffee
16.00-16.45
farewell lecture Prof.Dr. Jan Reedijk *
"M'n M's"
16.45-17.00
closing by Prof.Dr. Jaap Brouwer
17.00-18.30
farewell reception (central
hall Gorlaeus Laboratories)
19.00
farewell diner for invited
guests only
Jan
and Ada would prefer to make a donation to a charitable
project in Brazil. More information about this project
and how to donate can
be found here.
* Bij deze gelegenheid
wordt het toga-protocol gehanteerd en worden de hoogleraren
uitgenodigd mee te lopen in het cortège. Hoogleraren
wordt verzocht ons te berichten of ze deelnemen aan het
cortège en of ze vergezeld zullen worden door hun
partner (e-mail: snellenb@chem.leidenuniv.nl
onder vermelding van: afscheidsrede Reedijk). Hoogleraren
van buiten Leiden wordt verzocht hun eigen toga te dragen.
Participants
Abrahams, Jan Pieter Akerboom, Sebastiaan Albada, Ge van Andel, Dr. Noor van Angamuthu, Raja Arcis Castillo, Zulema Aromí, Dr. Guillem Aubel, Peter Baesjou, Patrick Bakker, Johan Balkaran, Jeral Barneveld, Sander Barrios, Dr. Leoni Bekooy, Ingrid Berding, Joris Bezemer, Ernst Bezouw, Stein van Bijlsma, Niels Birker, Paul Boelrijk, Alexandra Bol, Mark Bonnet, Sylvestre Boom, Stella van Bouwman, Lies Brouwer-Keij, Fennegien Bruggink, Alle Brussel, Jos van Buda, Francesco Buijs, Prof.Dr. Wim Buma, Wybren Jan Burik, Andrea Busropan, Demis Codee-van der Schilden, Karlijn Cooper, Geoff Cornelissen, Joost Corral, Eva Delanghe, Patrick Dessens, Liesbeth Diemen, John van Dijk, John van Donné-Op den Kelder, Dr. Gabriëlle Drent, Eite Driessen, Willem Drift, Robert van der Duivenvoorden, Boudewijn Elie, Dr. Cor Elsevier, Kees Elst, Hans van den Engberts, Prof.Dr. Jan Engelen, Dr. Mireille Engelfriet, Dr. Dik Erkelens, Kees Erkelens-Duijndam, Jopie Fan, Chunhua Favre, Loek Fichtinger-Schepman, Anne Marie Filippov, Dmitri Frenken, Joost Fu, Wen Tian Gagliardo, Marcella Gamba, Ilaria Gatteschi, Dante Gelder, Rene de Gerli, Alessandra Gluhoi, Andreea Gorkum, Remy van Gorter, Syb Goumans, Fedor Graaff, rag de Groeneveld, Lucas Groot, Huub de Groot, Odile de Guijt, Marieke Götz, Rens Haanepen, Martien Haanstra, Wim Haasnoot, Jaap Hage, Ronald Hal, Jaap van Heetebrij, Rob Hemert, Marc van Hendrickx, Harrie Hendriks, Hugo Hesselink, Theo Heuvel, Erik Jan van den Hoef, Ineke van der Hoeve, Paul van Hoeve-Brouwer, Geeske van Hollander, Johan Hoog, Paul de Hoog, Dr. Arie de Hoogendoorn, Ronald Hoogenraad, Marcel Hoonte, Frank ten Hotze-van Gorkum, Anna Houte, J.J. van Hovestreydt, Eric Huisman-Zilverentant, Carolien Hulsbergen, Frans IJdo, Daniel D.J.W. Jansen, Bart Jansen, Reinier Jaspers, Diederik Jesse, Wim Jong, Ana de Joosten, Dr.ir. Jacques Joya, Khurram Saleem Juurlink, Ludo Kaasjager, Vincent Kapteijn, Yolanda Kerckhoffs, Jessica kluwer, Sander Dr Kolen, Ad Dr. Kolnaar, Jeroen Kooistra, Marianne Kooyman, Patricia Koten, Prof.Dr. Gerard van Koval, Ira Kralingen, Kees van Kramer, Jurjen Kremleva, Ekaterina Kroes, Geert-Jan Kros, Alexander Kuil, Maxim Laane, Dr. Henk-Maarten Lammertsma, Koop Lapidaire, Hans Leeuwen, Fijs van Leeuwen, Jolanda van Leeuwen, Piet van Lefeber, Fons Leur-Struik, Astrid van Limburg, Bart Lok, Sandra Loon, Drs. Arjen van Lugtenburg, Prof.Dr. Johan Maaskant, Prof.Dr. Wim Maat, Leendert Marel, Gijs van der Marques, Patricia Matysik, Joerg Meiland, Hugo Molenbroek, Elwin Mooibroek, Tiddo Mulderink, Ir. Jan Muppa, Dr. Prasad Musson, Ruben Mutikainen, Ilpo Navarro-Ranninger, Prof. Dr. Carmen Nieuwenhuis, Heleen Nieuwenhuizen, Peter Nieuwenhuys, Bernard Noort, Leo van Nöllen, Erica Ochocki, Justyn Olsthoorn-Tieleman, Lian Oosterling, Ad Oroval, Mar M Orvig, Prof. Chris Oskam, Prof.Dr. Ad Osseweijer, Patricia Overkleeft, Hermen Pair, Kees le Pantoja López, Elena Paridon, John van Peters, Joop Peters, Prof.Dr. Frits Pievo, Roberta Poll, Tanja van de Ponec, Vladimir Pors-Varekamp, Loes Postema, Johan Quesada, Manuel Raap, Jan Reefman, Derk Reiding, Jurrie Reijen, Prof.Dr. Louis van Reus-Jorna, Anja de Ridder, Ivo Rietmeijer, Frits Rigamonti, Luca Rijn, Koos van Rijn, Jimmy van Rijt, Sabine van Robillard, Marc Robillard, George Rood, Mark Roon, Mirjam van Roubeau, Olivier Ruiter, Graham de Sanchez Costa, Jose Scanu, Sandra Schierbeek, Bram Schilstra, Dr. Marietje Schmidt, Kathrin Schoen, Lida Schuitema, Annemarieke Sikkema, Doetze Sliedregt, Karen Snellenberg, Yvonne Son, Martin van Sprengers, Jeroen Stassen, Arno Stassen-Flinzner, Kristel Talman, Dr. Ed Tampaxis, Christos Tanase Grecea, Stefania Tang, Siu-Ha Timmerman, Henk Trausel, Fanny Trijzelaar, Drs. Ben Tromp, Reynier Ubbink, Marcellus Valkema, Fridus Veer, Johan van der Veldhuizen, Yvonne Verhagen, Anja Vertegaal, Louis Verweij, Nelleke Viciano Chumillas, Marta Vijgh, Wim van der Visser-Chernova, Elena Volkers, Herman Vos, Renate de Vrieze, Kees Water, Leon van de Wenker, Erica Westmaas, Joyce Willems, Marian Witterland, Drs. Walter Wreesmann, Carel Zsom, Rob Zutphen, Steven van Zwaan, Drs. Hilde Zwan, Judith van der
Former
CBAC member:
You can help us a lot by checking/adding the email addresses
of other former CBAC members. Please check the list and
send the correct info to Yvonne Snellenberg.
You can login with the username/password sent to you by
mail. Look at the
email-addresses here.
Jan
and Ada would prefer to make a donation to a charitable
project in Brazil. More information about this project
and how to donate 